Scientist/Sr Scientist, Protein Sciences

Job Locations US-MA-Cambridge
Job Post Information* : Posted Date 3 weeks ago(6/3/2021 10:51 AM)
# of Openings
Research & Development
Job Post Information* : External Company URL
Location : Address
10 Wilson Road


Civetta Therapeutics (located in Cambridge, MA) is developing novel therapeutics through small molecule targeting of beta-propeller domain proteins.  Beta-propellers are a class of highly conserved structural proteins that are implicated in a range of indications, including multiple types of cancer, neurodegenerative and metabolic diseases.  Backed by Deerfield Management, Civetta was founded by William Sellers (Broad Institute and Dana-Farber Cancer Institute) and Eric Fischer (Dana Farber Cancer Institute and Harvard Medical School) with the mission to leverage the wide array of biologic functions in which propeller proteins participate to discover impactful new medicines for patients. 


We are building a team of talented, dedicated scientists who share our vision and our passion to discover groundbreaking new drugs to treat some of the most difficult diseases, including cancer.  If you are an accomplished life sciences professional that can bring significant energy, passion and expertise to the team, we welcome the opportunity to consider you for a position in this exciting, new company committed to thorough, mechanistically-driven science. 


The position

We are seeking an experienced and creative protein biochemist at the Scientist to Senior Scientist level to propel our gene-to-structure efforts in Protein Sciences as we build world-class platform capabilities to discover small molecule modulators of beta-propeller proteins. Reporting to the Director of Protein Sciences, this newly created position is highly visible within the organization, to our scientific leadership team, and the Executive Team.  This is an excellent opportunity for an experienced individual looking to work in a fast-paced, dynamic biotech environment. 



Key Responsibilities

  • Provide expertise and insight for construct design and purification protocols for protein production.
  • Perform expression and purification of challenging beta-propeller proteins to establish robust protocols that can be used internally or transferred to external (CRO) resources as needed.
  • Specify and procure necessary equipment, enabling technologies and reagents.
  • Collaborate productively with biochemistry and biophysics colleagues to generate protein reagents for assay development targeting beta-propeller proteins and multi-protein complexes.
  • Make intellectual contributions to all stages of drug discovery and project delivery.



  • Ph.D. degree and postdoctoral training (or equivalent) in biochemistry, structural biology or related discipline.
  • Expertise with expression of proteins and protein complexes using multiple host systems (mammalian, insect, bacterial).
  • Extensive protein biochemistry experience working with challenging proteins and multi-protein complexes.
  • Experience using specialized purification strategies, such as HIC and refolding from inclusion bodies.
  • Knowledge of protein structure and experience in the preparation of high-quality, concentrated protein samples for biophysical (SPR, ITC, DSF) and structural studies (NMR, X-ray, Cryo-EM).
  • Experience balancing CRO and internal resources to solve problems and drive progress.
  • Exceptional interpersonal and communication skills, and ability to effectively present data within the company and to other stakeholders.
  • Adept at working effectively within motivated cross-functional scientific teams to deliver project goals within timelines.


Civetta Therapeutics provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.


Notice to Third-Party Recruiters/Staffing Agencies: Recruitment is managed through Civetta Therapeutics’ Human Resources department. Resumes will only be accepted from staffing agency/recruiters if there is a signed contract in place. Recruiters are requested to not contact our hiring managers or employees directly to inquire about open positions or to present candidates. In the event a staffing agency/third-party recruiter submits a resume without a contract in place, the candidate submitted will be considered unsolicited and treated as if the candidate submitted their resume directly to Civetta, and no fee/payment will be paid. Recruiters interested in working with Civetta Therapeutics can submit their information to, and we will contact you if needed.






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