Senior Scientist/Associate Director, Computational Chemist

Job Locations US-MA-Cambridge
Job Post Information* : Posted Date 4 weeks ago(8/31/2021 3:04 PM)
# of Openings
Research & Development
Job Post Information* : External Company URL
Location : Address
10 Wilson Road


Civetta Therapeutics (located in Cambridge, MA) is developing novel therapeutics through the targeting of beta-propeller domain proteins.  Beta-propellers are a class of highly conserved structural proteins that are implicated in a range of indications, including multiple types of cancer, neurodegenerative and metabolic diseases.  Backed by Deerfield Management, Civetta was founded by William Sellers (Broad Institute and Dana-Farber Cancer Institute) and Eric Fischer (Dana Farber Cancer Institute and Harvard Medical School) with the mission to leverage the wide array of biologic functions in which propeller proteins participate to discover impactful new medicines for patients. 

We are building a team of talented, dedicated scientists who share our vision and our passion to discover groundbreaking new drugs to treat some of the most difficult diseases, including cancer.  If you are an accomplished life sciences professional that can bring significant energy, passion, and expertise to the team, we welcome the opportunity to consider you for a position.


The ideal candidate will have hands-on experience working with multidisciplinary teams in drug discovery.  Experience participating in structure-based programs from Hit Identification to Clinical Candidate is highly desirable.



  • Opportunity to utilize computational methods to discover and advance structure-based drug discovery programs. Equally important, the opportunity to develop and deploy advanced computational approaches to build and elucidate the beta-propeller platform from a structural and ligand perspective.
  • Work as part as part of drug discovery teams to design novel small molecule agents
  • Work as part of the Propeller Platform team to enable proprietary structural or pharmacological insights. Partner with Data Sciences to continue the buildout of a robust knowledge base, providing unique insights to the entire discovery team.
  • Apply computational methods across the propeller platform and drug discovery pipeline including small molecule docking, homology modeling, free energy calculations, quantum mechanics calculations, QSAR models development, and pharmacophore elucidation
  • Develop hypotheses to understand propeller structures, drug binding and SAR by application of molecular dynamics
  • Compound library design and the application of virtual screening to identifying new lead material


Basic qualifications:

  • Ph.D. degree in computational chemistry or related discipline with knowledge of medicinal chemistry
  • Minimum 10 years of industry experience. Civetta will explore candidates with a wide range of experience levels and title for the successful candidate will be commensurate with experience
  • Experience using structure-based design tools, such as the Schrödinger suite, OpenEye, CCG, MOE, and others
  • Experience with ligand- and property-based drug design
  • Proficiency with computer programing/scripting languages, such as KNIME, C++ and Python
  • Strong interpersonal as well as written and oral communication skills
  • Organizational skills, along with a demonstrated ability to work both independently and collaboratively among a small, highly committed team


Civetta Therapeutics provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.


Notice to Third-Party Recruiters/Staffing Agencies: Recruitment is managed through Civetta Therapeutics’ Human Resources department. Resumes will only be accepted from staffing agency/recruiters if there is a signed contract in place. Recruiters are requested to not contact our hiring managers or employees directly to inquire about open positions or to present candidates. In the event a staffing agency/third-party recruiter submits a resume without a contract in place, the candidate submitted will be considered unsolicited and treated as if the candidate submitted their resume directly to Civetta, and no fee/payment will be paid. Recruiters interested in working with Civetta Therapeutics can submit their information to, and we will contact you if needed.







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