Head of Chemistry

Job Locations US-MA-Cambridge
Job Post Information* : Posted Date 4 weeks ago(8/31/2021 1:41 PM)
# of Openings
Research & Development
Job Post Information* : External Company URL
Location : Address
10 Wilson Road


Civetta Therapeutics is recruiting an executive “drug hunting” leader in small molecule drug discovery.

Located in Cambridge, MA, Civetta is developing novel therapeutics through the targeting of beta-propeller domain proteins.  Beta-propellers are a class of highly conserved structural proteins that are implicated in a range of indications, including multiple types of cancer, neurodegenerative and metabolic diseases.  Backed by Deerfield Management, Civetta was founded by William Sellers (Broad Institute and Dana-Farber Cancer Institute) and Eric Fischer (Dana Farber Cancer Institute and Harvard Medical School) with the mission to leverage the wide array of biologic functions in which propeller proteins participate to discover impactful new medicines for patients. 

We are building a team of talented, dedicated scientists who share our vision and our passion to discover groundbreaking new drugs to treat some of the most difficult diseases, including cancer.  If you are an accomplished life sciences professional that can bring significant energy, passion, and expertise to the team, we welcome the opportunity to consider you for a position.


The position.  We are seeking a Head of Chemistry (Vice President, Chemistry or Senior Vice President, Drug Discovery; title will be commensurate with experience) to propel our Drug Discovery and Development efforts. The candidate will lead the building of a world-class drug discovery capability for discovering small molecule modulators of propeller proteins leveraging cutting edge techniques to target protein-protein interactions. Critically, the candidate will be a critical provider of senior scientific and organizational leadership to Civetta.


Key Responsibilities

  • Lead and build the small molecule discovery team and capability comprised of medicinal and computational chemistry
    • Depending upon the candidate, additional responsibilities may be included from among process chemistry, analytical chemistry, early CMC, discovery DMPK, protein sciences & structural biology, biophysics and hit finding or project management
  • Assume a strong leadership role in developing, implementing and communicating the overall platform and pipeline scientific and corporate strategy. Articulating effectively in both internal and external settings
  • Build a functional and scalable operating model that utilizes both internal team members and external resources (consultants, CROs and scientific collaborators) to advance a range of programs
  • Oversee the discovery, optimization and advancement of small molecule modulators of propellers into IND enabling studies
  • Partner with the Civetta Platform team to aid in the development of b-propeller capabilities and strategy. Including helping to develop chemical tools to enable biology and chemical biology efforts
  • Partnering with Civetta’s Legal team, proactively manage and drive the Intellectual Property strategy and patent portfolio.
  • Work closely with CEO, CSO, investors, founders and board members




  • Ph.D. in Chemistry or related field with 15+ years of industry experience
  • Demonstrated hands-on experience leading the delivery of multiple small molecule drug candidates into IND enabling studies and clinical development
    • A track record of discovering assets that have demonstrated clinical POC or have achieved registrational approval is preferred
    • Experience in multiple therapeutic areas is preferred
  • The ideal candidate will have hands-on experience in post-Development Candidate IND enabling, translational and/or clinical development activities
  • Significant experience in recruiting, leading and retaining diverse teams of medicinal and computational chemists
    • Ideally, experience leading chemistry adjacent discovery or development functions is preferred
  • Demonstrated experience in strategic resourcing – conceiving, building and managing a balanced team of internal and global, external discovery function is required
  • Demonstrable leadership and vision with the clear ability to work effectively with leadership peers and external scientific partners
  • Demonstrable experience and strategic expertise in navigating, securing and maintain a robust intellectual property portfolio. Demonstrated experience in developing an IP strategy beyond patent filings is preferred
  • Exceptional interpersonal and communication skills, and ability to effectively articulate strategy and present data within the company and to diverse external audiences
    • Experience in successfully pitching to investors or pharma/biotech partners is ideal
  • A passion to tackle challenging innovative problems and to undertake the mission critical advancement of investigational agents to waiting patients



Civetta Therapeutics provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.


Notice to Third-Party Recruiters/Staffing Agencies: Recruitment is managed through Civetta Therapeutics’ Human Resources department. Resumes will only be accepted from staffing agency/recruiters if there is a signed contract in place. Recruiters are requested to not contact our hiring managers or employees directly to inquire about open positions or to present candidates. In the event a staffing agency/third-party recruiter submits a resume without a contract in place, the candidate submitted will be considered unsolicited and treated as if the candidate submitted their resume directly to Civetta, and no fee/payment will be paid. Recruiters interested in working with Civetta Therapeutics can submit their information to contact@civettatherapeutics.com, and we will contact you if needed.






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