Principal Scientist, Proteomics

Job Locations US-MA-Cambridge
Job Post Information* : Posted Date 3 weeks ago(9/27/2021 4:59 PM)
# of Openings
Research & Development
Job Post Information* : External Company URL
Location : Address
10 Wilson Road


Civetta Therapeutics (located in Cambridge, MA) is developing novel therapeutics through small molecule targeting of beta-propeller domain proteins.  Beta-propellers are a class of highly conserved structural proteins that are implicated in a range of indications, including multiple types of cancer, neurodegenerative and metabolic diseases.  Backed by Deerfield Management, Civetta was founded by William Sellers (Broad Institute and Dana-Farber Cancer Institute) and Eric Fischer (Dana Farber Cancer Institute and Harvard Medical School) with the mission to leverage the wide array of biologic functions in which propeller proteins participate to discover impactful new medicines for patients. 

We are building a team of talented, dedicated scientists who share our vision and our passion to discover groundbreaking new drugs to treat some of the most difficult diseases, including cancer.  If you are an accomplished life sciences professional that can bring significant energy, passion and expertise to the team, we welcome the opportunity to consider you for a position.

The position

We are seeking an experienced and creative proteomic scientist to help us discover small molecule modulators of beta-propeller proteins, to support validation of new targets, and to help propel our ongoing drug discovery programs.  This is an excellent opportunity for individuals looking to work in a fast-paced, dynamic biotech environment. 


  • Using internal and external (CRO) resources, build a world class protein mass spectrometry capabilities to drive the Civetta beta-propeller platform to:
    • Discover and quantify proteins which interact with, or are in proximity to, beta-propeller domain-containing proteins using fit for purpose labeling technologies
    • Quantify propeller interactions with small molecules
    • Implement discovery proteomics and targeted single and multiplexed protein detection and quantification to enable target evaluation and discovery and compound selectivity profiling
    • Enable covalent fragment discovery
    • Establish hit finding approaches via intact mass spectrometry
  • Help to specify and procure necessary equipment, enabling technologies and reagents
  • Collaborate productively with cell biology and chemistry colleagues on design and execution of chemical biology experiments targeting beta-propeller proteins and multi-protein complexes
  • Make intellectual contributions to all stages of drug discovery and project delivery



  • PhD in proteomics, chemical biology, analytical chemistry or related field with 7+ years related industry experience (biotech/pharma)
  • Expertise in use and maintenance of but not limited to Orbitrap mass spectrometers (i.e. QE+, Lumos)
  • Expertise in proteomic sample preparation (i.e. digestion, isobaric labeling, offline HPLC fractionation)
  • Proven ability to establish and optimize proteomic discovery platform via both DDA and DIA acquisition modes
  • Proficiency in data processing (Proteome Discoverer, MaxQuant) and data analysis with a fundamental knowledge of statistics
  • Experience balancing CRO and internal resources to solve problems and drive progress.
  • Exceptional interpersonal and communication skills, and ability to effectively present data within the company and to other stakeholders.
  • Independence in designing and implementing experiments to enable ligand discovery, target identification and/or target validation using chemical probes, mass spectrometry and related tools.



Civetta Therapeutics provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.


Notice to Third-Party Recruiters/Staffing Agencies: Recruitment is managed through Civetta Therapeutics’ Human Resources department. Resumes will only be accepted from staffing agency/recruiters if there is a signed contract in place. Recruiters are requested to not contact our hiring managers or employees directly to inquire about open positions or to present candidates. In the event a staffing agency/third-party recruiter submits a resume without a contract in place, the candidate submitted will be considered unsolicited and treated as if the candidate submitted their resume directly to Civetta, and no fee/payment will be paid. Recruiters interested in working with Civetta Therapeutics can submit their information to, and we will contact you if needed.






Sorry the Share function is not working properly at this moment. Please refresh the page and try again later.
Share on your newsfeed